Work

End-tail soaking strategy toward robust and biomimetic sandwich-layered hydrogels for full-thickness bone regeneration

Year: 2025

Type: article

Abstract: studies further revealed that these SL hydrogels achieved restrictive pro-vascular regeneration through their stratified structure, thereby promoting the differentiation of osteoblasts. Simultaneously, the mechanical cues of stratified structure could mediate macrophage phenotype transitions in accordance with stem cell-osteoblast differentiation process via the PI3K-AKT pathway, resulting in robust osteogenesis and high-quality bone reconstruction. This facile yet efficient strategy of turning anisotropic hydrogel offers a promising alternative for full-thickness repair of bone defects, which is also significantly imperative to achieve high-performance scaffolds with specific usage requirements and expand their clinic applicability in more complex anisotropic tissues.

Source: Bioactive Materials

DOI: 10.1016/j.bioactmat.2025.02.045