Work

Severe Late-Onset Anthracycline-Induced Cardiotoxicity in Breast Cancer Survivor Patient

Year: 2025

Type: article

Abstract: BACKGROUND: Left ventricular (LV) dysfunction is a common and serious complication from cancer treatment. One of the common regimens that can cause cardiotoxicity is anthracycline, and anthracycline-induced cardiotoxicity may manifest after several years. CASE SUMMARY: A 32-year-old woman presented with heart failure syndrome late after chemotherapy administration for breast cancer therapy. Several months after chemotherapy completion, patient presented with overt LV dysfunction. The guideline-directed medical treatment was initiated. Patient demonstrated gradual recovery and progressive improvement of myocardial systolic performance with LV thrombus resolution after 5-month evaluation. DISCUSSION: The recognition of cancer therapy-related cardiac dysfunction (CTRCD) is important since early detection and treatment with heart failure treatment provide a good functional recovery and long-term prognosis. The clinical application of longitudinal strain and myocardial work echocardiography in CTRCD cases for therapeutic response tracking and prognostication purposes is recommended. TAKE-HOME MESSAGE: Long-term postchemotherapy echocardiography evaluation especially in high-risk CTRCD criteria is of utmost importance due to the possibility of late-onset CTRCD.

Source: JACC Case Reports

DOI: 10.1016/j.jaccas.2024.103189

Authors: Rizky Hendiperdana, Amiliana M. Soesanto

Institution: University of Indonesia

Language: English

Topic: Chemotherapy-induced cardiotoxicity and mitigation

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $850