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Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?

Year: 2025

Type: editorial

Abstract: The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of the spike protein in SARS-CoV-2. However, the evolutionary benefit of this binding to the virus still remains unclear. Herein, we put forward with rationale and supporting evidence that the binding of fibrinogen to its more conserved NTD is an immune evasion strategy adopted by the virus to outsmart the NTD targeted neutralizing antibodies.

Source: ACS Pharmacology & Translational Science

DOI: 10.1021/acsptsci.5c00122

Authors: Saroj Kumar Panda, Shashi Singh, Parth Sarthi Sen Gupta

Institutions: The University of Texas at Arlington, D Y Patil International University

Language: English

Topic: SARS-CoV-2 and COVID-19 Research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4408609477

Cites: 12

Cited by: 6

Related to: 10