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Mammary tumor development induces perturbation of liver glucose metabolism with inflammation and fibrosis

Year: 2025
Type: article
Abstract: This work demonstrates that the spontaneous development of non-metastatic mammary tumors triggers hepatic activation of endogenous glucose production pathways, coinciding with the onset of insulin resistance. This finding suggests a significant cross talk between tumors and the liver during tumorigenesis, aiming at enhancing glucose production to meet the elevated energy demands of the tumor. Understanding this interaction could provide insights into metabolic alterations associated with cancer and lead to potential therapeutic targets to inhibit tumor metabolism.
DOI: 10.1152/ajpendo.00498.2024
Authors: Anouk Charlot, Anthony Bringolf, Joris Mallard, Amélie Jaulin, Emilie Crouchet, Anne-Laure Charles, Delphine Duteil, Fabien Alpy, Catherine-Laure Tomasetto, Thomas F. Baumert, Joffrey Zoll
Institutions: Inserm, Institute for Translational Medicine and Liver Disease, Université de Strasbourg, Institut de Cancérologie Strasbourg, Hôpitaux Universitaires de Strasbourg, Institut de Chirurgie Guidée par l'Image
Language: English
Open Access status: bronze
OpenAlex ID: W4408612814
FWCI: 0.522
Cites: 27
Cited by: 2
Related to: 10