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Disease‐Associated Risk Variants and Expression Levels of the lncRNA , CDKN2B ‐ AS1 , Are Associated With the Progression of HCC

Year: 2025
Type: article
Study design: Observational Study
Abstract: The most susceptible loci of hepatocellular carcinoma (HCC) identified by genome-wide association studies are located in non-coding regions. The antisense non-coding RNA at the INK4 locus (ANRIL), also known as cyclin-dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1), is a long non-coding (lnc)RNA situated within and antisense to genes encoding CDKN2A/B on chromosome 9p21.3. Single-nucleotide polymorphisms (SNPs) within CDKN2B-AS1 are associated with several cancer types, but their impacts on HCC remain unclear. In this study, we investigated the effects of CDKN2B-AS1 SNPs on both the susceptibility to HCC and its clinicopathological development. Five CDKN2B-AS1 SNP loci-rs564398 (T/C), rs1333048 (A/C), rs1537373 (G/T), rs2151280 (A/G) and rs8181047 (G/A)-were analysed using a TaqMan allelic discrimination assay for genotyping in a cohort of 810 HCC patients and 1190 healthy controls. Under the dominant model, HCC patients with at least one minor C-allele of rs564398 showed a lower risk of liver cirrhosis (odds ratio (OR) = 0.677). Additionally, HCC patients with the GT + TT genotype of rs1537373 had a reduced risk of developing large tumours (T3 + T4) and advanced clinical stages (III/IV), particularly in the male population (OR = 0.644 and 0.679). Furthermore, data from The Cancer Genome Atlas revealed that CDKN2B-AS1 expression levels were elevated in HCC tissues compared to normal tissues and were correlated with advanced T stages, high histological grades and poor prognoses. Our findings suggest that CDKN2B-AS1 levels and its polymorphic variants at rs564398 and rs1537373 may influence the clinicopathological development and progression of HCC in a Taiwanese population.
DOI: 10.1111/jcmm.70496
Authors: Kuan‐Chun Hsueh, Hsiang‐Lin Lee, Kuo‐Hao Ho, Lun‐Ching Chang, Shun‐Fa Yang, Ming‐Hsien Chien
Institutions: National Chung Hsing University, Tungs' Taichung MetroHarbor Hospital, Chung Shan Medical University Hospital, Chung Shan Medical University, Taipei Medical University, Florida Atlantic University, Taipei Medical University Hospital, Wan Fang Hospital
Language: English
Subfield: Cancer Research
Open Access status: gold
Estimated APC paid: $5,210
OpenAlex ID: W4408615400
FWCI:
Cites: 47
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Related to: 10