Year: 2025
Type: article
Abstract: Hepatitis E virus (HEV) is an emerging zoonotic pathogen and it is associated with chronic hepatitis E virus infection (CHE) in immuno-suppressed patients due to failure of viral clearance. A network of the CHE-associated-differentially expressed genes (DEGs) is known. Hence, a comprehensive assessment of the known protein-protein interaction (PPI) network is of interest. After network clustering, the hub gene-associated microRNAs (miRNAs) were explored and subsequently, these identified miRNAs (miR-129-2-3p, miR-130a-3p, miR-138-5p, miR-212-3p, miR-221-3p, miR-27b-3p and miR-29c-3p) were undertaken for enrichment analysis. It should be noted that these miRNAs are significantly associated with Hepatitis E virus infection for further validation and analysis.
Source: Bioinformation
Authors: Zoya Shafat, Murshad Ahmed, Anam Farooqui, Nazim Khan, Shama Parveen
Institution: Jamia Millia Islamia
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Awards: G1226736056, G6875984631
OpenAlex ID: W4408615668