Work

Polymorphisms in the calcium voltage-gated channel subunit Alpha1 D (CACNA1D) gene are associated with spontaneous preterm birth in Taiwanese women

Year: 2025

Type: article

Abstract: PURPOSE: Calcium signaling is essential for immune function, myometrial contractions, and hormone secretion, all of which contribute to preterm birth. In this study, we investigated the associations of 3 single-nucleotide polymorphisms (SNPs) in CACNA1D gene, which encodes the Cav1.3 calcium channel, with the risk of spontaneous preterm birth (sPTB). METHODS: A hospital-based case-control study was conducted with 112 women of sPTB and 1120 term control women. Three CACNA1D SNPs (rs9810888 T/G, rs1045958 C/T, and rs881883 G/A) were genotyped. RESULTS: = 0.03). However, no significant associations were observed for the other 2 SNPs. Haplotype analysis revealed no significant differences between the case and control groups. CONCLUSION: Our findings suggest that the intronic rs9810888 T/G variant of CACNA1D gene protects against sPTB in Taiwanese women.

Source: Journal of the Formosan Medical Association

DOI: 10.1016/j.jfma.2025.03.010

Authors: Tzu-Yang Chang, Tzu-Hsiang Kao, Yi-Hsiu Kuo, Chia-Yu Chen, Chie-Pein Chen

Institution: Mackay Memorial Hospital

Language: English

Topic: Preterm Birth and Chorioamnionitis

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500