Work

The intraoperative SEEG and 18FDG-PET tailored temporal lobe resection (iSP-TR) for the tissue-spearing surgical treatment of drug-resistant mesial temporal lobe epilepsy: how we do it

Year: 2025

Type: article

Abstract: Background For drug-resistant mesial temporal lobe epilepsy (MTLE), surgery is recommended. There is no evidence of a seizure outcome advantage of temporal lobectomy over other strategies despite the high risks of this surgical procedure. Methods We describe a Temporal Resection guided by intraoperative stereo-electroencephalography (iSEEG) and the 18FluoroDeoxyGlucose PET (18FDG PET) (iSP-TR) to treat lesional MTLE. We avoided functional cortical areas using navigated Transcranial Magnetic Stimulation (nTMS). Conclusion iSP-TR allows for a spare brain parenchyma compared to temporal lobectomy without compromising seizure outcomes.

Source: Acta Neurochirurgica

DOI: 10.1007/s00701-025-06491-x

Authors: Francesca Battista, Riccardo Carrai, Antonello Grippo, Alessandro Della Puppa

Institutions: Azienda Ospedaliero-Universitaria Careggi, University of Florence

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,990