Work

Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats

Year: 2025

Type: article

Abstract: PURPOSE: This study aimed to assess the effectiveness of different pulse widths in suppressing bladder overactivity using tibial nerve stimulation (TNS) in cats. METHODS: Hook electrodes were implanted on the left tibial nerve. Cystometry was conducted by infusing either acetic acid (AA) or normal saline (NS). TNS was applied at intensities of 2-4 times the threshold (T) with pulse widths ranging from 60 to 624 µsec. Cystometrograms were used to evaluate the impact of different pulse widths on the micturition reflex. RESULTS: Bladder capacity (BC) was significantly reduced to 49.71% ± 6.76% of the NS control level (8.58 ± 1.70 mL) due to AA-induced bladder overactivity (P < 0.001). During AA infusion, TNS at pulse widths of 60, 210, 420, and 624 µsec significantly increased BC to 70.65% ± 9.06%, 73.22% ± 6.28%, 73.79% ± 8.56%, and 76.25% ± 7.95% of the NS control level, respectively (P < 0.001). No significant differences were observed among the four pulse widths (P > 0.05). The threshold intensity (T) was higher at 60 µsec than at 624 µsec (P < 0.01), while T at 210 µsec, 420 µsec, and 624 µsec showed no significant differences (P > 0.05). CONCLUSIONS: All four pulse widths demonstrated inhibitory effects on bladder overactivity. However, no significant differences were observed among the four pulse widths.

Source: European journal of medical research

DOI: 10.1186/s40001-025-02453-2

Authors: Dongsheng Shang, Haoyu Sun, Han Deng, Gongyue Liu, Limin Liao, Xing Li

Institutions: Capital Medical University, Wenzhou Medical University, China Rehabilitation Research Center, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,190