Association between Hemoglobin Glycation Index and In-Hospital all-cause mortality of patients with Congestive Heart Failure: a retrospective study utilizing the MIMIC-IV database
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: The aim of this study was to explore the relationship between the hemoglobin glycation index (HGI) of Congestive Heart Failure (CHF) patients and their risk of mortality within 365 days. Patients and methods: The Medical Information Mart for Intensive Care (MIMIC-IV) database supplied the patient data for this study, which was categorized into quartiles based on the HGI. The primary endpoint was all-cause mortality within a 365-day period. Kaplan-Meier (K-M) analysis was utilized to compare this primary endpoint across the four aforementioned groups. The relationship between the HGI and the endpoint was examined using restricted cubic splines (RCS) and a Cox proportional hazards analysis. Results: A total of 985 patients were included in this study. HGI was significantly associated with 30 days mortality (15.9%; HR, 0.79; 95% CI, (0.67~0.92); P=0.003) and 60 days mortality (19.3%; HR, 0.83; 95% CI, (0.72~0.96); P=0.011) and 90 days mortality (22.1%; HR, 0.86; 95% CI, (0.75~0.99); P=0.031) and 365 days mortality (30.7%; HR, 0.97; 95% CI, (0.86~1.09); P=0.611) in patients with critical CHF in the completely adjusted Cox proportional risk model. RCS analysis revealed a U-shaped relationship between HGI and outcome events. KM curves survival analysis suggests a correlation between 30 days and 365 days mortality in HGI and CHF patients. Conclusions: A higher HGI has a more protective effect than a low HGI for patients with CHF and was directly associated with short-term mortality rates. These findings may be helpful in the management of patients with CHF.
Source: Frontiers in Endocrinology
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408642772