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Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N ‑acetylamino malonic acid monoesters

Year: 2025

Type: article

Abstract: Electrochemical synthesis of 2-aminoprolines capitalizes on anodic decarboxylation-intramolecular amidation of readily available N-acetylamino malonic acid monoesters. The decarboxylative amidation under Hofer−Moest reaction conditions proceeds in an undivided cell under constant current conditions in aqueous acetonitrile and provides an access to N-sulfonyl, N-benzoyl, and N-Boc-protected 2-aminoproline derivatives.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.21.50

Authors: Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis, Edgars Suna

Institutions: Latvijas Organiskās Sintēzes Institūts, University of Latvia

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

OpenAlex ID: W4408655714

FWCI:

Cites: 15

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Related to: 10