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An Unusual Case of Primary Aldosteronism with Negative 68Ga-Pentixafor PET/CT and Positive FDG-PET/CT in a Left Adrenal Adenoma

Year: 2024

Type: article

Abstract: A 65-year-old male with systemic hypertension, progressively rising aldosterone levels, low plasma renin activity, contrast Magnetic resonance imaging (MRI) described left adrenal lesion isointense to liver parenchyma on T2-weighted images and other features suggestive of left adrenal incidentaloma underwent 68 Ga-Pentixafor Positron emission tomography-computed tomography (PET/CT), which unexpectedly did not show tracer uptake in the known left adrenal adenoma. However, the said nodule showed significant focal tracer uptake on F-18 Fluorodeoxyglucose (FDG)-PET/CT that was done within 2 weeks of 68 Ga-Pentixafor PET/CT study. This unusual finding, which has hitherto been unreported in known patients of primary aldosteronism needs further exploration to determine its clinical significance.

Source: Indian Journal of Nuclear Medicine

DOI: 10.4103/ijnm.ijnm_150_24

Authors: Aamir Nazar, Gaurav Malhotra, Sandip Basu

Institutions: Bhabha Atomic Research Centre, Homi Bhabha National Institute, Tata Memorial Hospital

Language: English

Topic: Hormonal Regulation and Hypertension

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4408658098

FWCI:

Cites: 14

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Related to: 10