Work

Iron Porphyrins and Iron Salens as Highly Enantioselective Catalysts for the Ring-Expansion Reaction of Epoxides to Tetrahydrofurans

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Iron porphyrins have been found to be efficient catalysts for the ring-expansion reaction of epoxides with alkenes to give the corresponding tetrahydrofurans; very low loadings (down to 1 mol %) are sufficient to achieve high yields (up to 98%). Additionally, an iron(III) salen complex based on the axially chiral 1,1-binaphthalene backbone has been shown to catalyze the reaction with high enantioselectivity ( e.g ., 92% ee for calyxolane A).

Source: Organic Letters

DOI: 10.1021/acs.orglett.5c00767

Authors: Mehmet Ulutürk, Mehmet Göllü, Tahir Tilki, Erkan Ertürk

Institutions: Süleyman Demirel Üniversitesi, Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK Marmara Research Center, Middle East Technical University, Gebze Technical University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funder: Türkiye Bilimsel ve Teknolojik Araştırma Kurumu