Year: 2024
Type: article
Abstract: Periodontitis is a notable public health issue impacting more than 1 billion individuals globally, and its connection with volatile organic compounds (VOCs) has attracted growing interest. This review seeks to explore the existing knowledge on the link between VOCs and periodontitis. MATERIALS AND METHODS: An extensive literature review was performed to pinpoint key VOCs associated with periodontitis. RESULTS: The review revealed that several VOCs, such as hydrogen sulfide, methanethiol, indole, limonene, formaldehyde, 1,4-dichlorobenzene, 2-Aminothiazoline-4-carboxylic acid, ethyl acetate, methyl mercaptan, dimethyl sulfide, acetone, pyridine, picolines, o-xylene, mandelic acid, and N-acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine, are linked to periodontitis, with some contributing to heightened oral infection, direct tissue harm, oral malodor, and inflammatory responses, while the causality of this phenomenon remains unclear as it is uncertain which event occurs first. CONCLUSION: This review enumerates the VOCs that may either contribute to or arise from periodontitis; hydrogen sulfide appears to be the most extensively studied VOC in the context of periodontitis. This review highlights the intricate relationship between VOCs and periodontitis and underscores the necessity for additional research to clarify the mechanisms underlying this association and to guide the creation of effective prevention and treatment strategies.
Source: Galen Medical Journal
Institutions: Rafsanjan University of Medical Sciences, Islamic Azad University of Shiraz, Ahvaz Jundishapur University of Medical Sciences, Shahrekord University, Shahrekord University of Medical Sciences, Shiraz University, Shiraz University of Medical Sciences, Tehran University of Medical Sciences, Tabriz University of Medical Sciences
Language: English
Subfield: Periodontics
Field: Dentistry
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408662827