The second generation metagenomic sequencing of cerebrospinal fluid for diagnosis of non-eschar scrub typhus
Year: 2025
Type: article
Study design: Case Report
Abstract: Tsutsugamushi disease, is an infectious disease transmitted by ticks and caused by the rickettsiella. It is characterized by eschar, fever, rash, and flu-like symptoms. However, diagnosing atypical cases without an eschar and with negative Weil-Felix test results poses a significant diagnostic challenge. This study presents a noteworthy case of non-eschar typhus which was effectively diagnosed using advanced next-generation sequencing (mNGS) of cerebrospinal fluid (CSF) samples.
Source: Oxford Medical Case Reports
DOI: 10.1093/omcr/omae198
Authors: Shujing Li, Shujing Li, Sufang Zhang, Tao Zhou, Zhe Ge, Yi Li, JiYing Zhang, Yifei Zhu, Shaoying Li, Shaoying Li
Institutions: Kunming Medical University, Dali University
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,103
OpenAlex ID: W4408663419