Work

L -Carnitine Attenuates Cigarette Smoke-Induced Apoptosis, Cytotoxicity, and Oxidative Stress in Human Vena Cava Endothelial Cells

Year: 2025

Type: article

Abstract: Background: Cigarette smoke is widely recognized as a cause of oxidative stress. There is substantial evidence indicating that it can cause changes in the structure of the endothelium, leading to an increase in reactive oxygen species (ROS). l-carnitine (LC) is a compound that facilitates the transport of fatty acids to mitochondria and contributes to energy production and cellular apoptosis. Hence, this study aimed to explore the protective properties of LC against the cytotoxic effects triggered by cigarette smoke.

Source: Applied In Vitro Toxicology

DOI: 10.1089/aivt.2024.0028

Authors: Amin Reihani, Daniel Jahani, Fatemeh Shaki, Mohamad Shokrzadeh

Institutions: Mazandaran University of Medical Sciences, Universitat de Barcelona

Language: English

Topic: Antioxidant Activity and Oxidative Stress

Subfield: Biochemistry

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Mazandaran University of Medical Sciences