Work

Mechanism of Unexpected In-Trans Post-PKS Polyketide Reduction in Cochliodone Biosynthesis

Year: 2025

Type: article

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.5c03717

Authors: Christopher Sarmales-Murga, Michio Sato, Motoki Kosaka, Fumito Akaoka, Kenji Watanabe

Institutions: Shizuoka University, University of Shizuoka

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: Uehara Memorial Foundation, Ministry of Education, Culture, Sports, Science and Technology, Secom Science and Technology Foundation, Japan Society for the Promotion of Science

Awards: G1468744672, G1756637430, G1874725740, G2236896281, G2716968438, Identification of target molecules based on self-resistance gene-directed genome mining, Understanding a mechanism of an onset of colorectal cancer by colibactin and finding compounds inhibiting colibactin biosynthetic enzymes, G4483207381, G4815956992, G5949476863, G6337925402, G66961060, Toward engineered biosynthesis of drugs in human cells, G7231557068, Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymes

OpenAlex ID: W4408664644

FWCI: 1.939

Cites: 35

Cited by: 4

Related to: 10