Work

Application and Synthesis of a New Hybrid Heterocyclic Derivative with Antioxidant Evaluation

Year: 2024

Type: conference-paper

Abstract: New hydrazinecarboximidamide derivatives were successfully synthesized with excellent yields.These compounds have been proven to be potent inhibitors of acetylcholinesterase and tubulin, and they also exhibit significant antioxidant effects.Furthermore, an ADMET study was conducted, which suggests that these compounds not only possess the potential to cross the blood-brain barrier.These findings allow us to consider this product as a promising candidate for future medicinal development, particularly in the treatment of neurodegenerative diseases and cancer.

DOI: 10.3390/ecsoc-28-20125

Authors: Amira Ait Belkacem, Roumaissa Djaafarou, Selma Rabhi

Institution: University Frères Mentouri Constantine 1

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4408674808

FWCI:

Cites: 10

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Related to: 10