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An optical fiber aspirin sensor with molecularly-imprinted polymer coating on fiber core surface as transducer

Year: 2025
Type: article
Abstract: An optical fiber chemical sensor for detecting acetylsalicylic acid (ASA) in aqueous sample solutions has been developed by using an ASA imprinted Chitosan membrane coated on an optical fiber surface as a transducer. The integration of molecularly imprinted polymer (MIP) membrane as an optical fiber chemical sensor’s transducer significantly improved sensor’s selectivity. In addition, Chitosan is a basic polymer, contains an amine group in each of its glucose ring. ASA is a weak acid. The weak acid/base reaction concentrates ASA from sample solution into MIP membrane and significantly improve the sensor’s sensitivity. Compared with a bare optical fiber probe for detecting ASA, the sensor of this work achieved a 2583 times sensitivity improvement due to the function of concentrating ASA from sample solution into the MIP membrane. The sensor achieved a detection limit of 0.069 µg/mL, which is 5–10 time lower when compared with traditional UV/Vis optical absorption spectrometric methods for detecting ASA. This sensor detects ASA’s intrinsic optical absorption spectrum as a sensing signal, and no additional reagent is needed for detecting ASA in a sample solution. The sensor’s response to ASA is reversible because the adsorption of ASA into the MIP is a reversible process. The sensor has a fast response with response time of 2 min. The sensor has been used for analyzing ASA in an aspirin drug product available from a local pharmacy store. Analytical result obtained with the developed sensor agrees well with that obtained by using a traditional UV/Vis optical absorption spectrometric method.
DOI: 10.1016/j.microc.2025.113422
Authors: Jason D. McCaslin, Shiquan Tao
Language: English
Field: Chemistry
Open Access status: hybrid
Estimated APC paid: $4,000
OpenAlex ID: W4408675209
FWCI: 2.21
Cites: 42
Cited by: 6
Related to: 10