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Remdesivir for the Treatment of Human Coronavirus OC43 Encephalitis

Year: 2025
Type: article
Study design: Case Report
Abstract: Human coronavirus OC43 (HCoV-OC43) is predominantly associated with mild respiratory infections. HCoV-OC43 also has neuroinvasive properties, and severe encephalitis has been described in immunocompromised patients, with fatal outcomes due to the lack of specific antiviral treatment. We report a case of severe febrile encephalitis attributed to HCoV-OC43 that progressively worsened over 3 months in a 65-year-old immunocompromised man. Clinical symptoms improved remarkably after treatment with remdesivir, with an increase of the Glasgow Coma Score from 8 to 14 within 7 days.
DOI: 10.1002/jmv.70314
Authors: Jacques Fourgeaud, Pascal Turlure, Marine Dupont, Nicolas Veyrenche, Clémence Busquet, Sophie Alain, Marianne Leruez‐Ville, Nolwenn M. Dheilly, Pierre Frange
Language: English
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,730
OpenAlex ID: W4408676570
FWCI: 2.113
Cites: 12
Cited by: 3
Related to: 10