Revisiting lymph node guidelines: limited lymph node examination might be sufficient for elderly gastric cancer patients
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: Whether limited examined lymph node (ELN) number is comparable to recommended ELN number for long-term outcomes remains controversial in elderly gastric cancer (GC) patients. The purpose of this study was to assess the long-term survival between limited ELN number and recommended ELN number in elderly GC patients. Methods: Elderly GC patients over 75 years old from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively reviewed. The long-term cancer-specific survival (CSS) and overall survival (OS) were compared between the limited ELN number group (ELN <15, limited group) and recommended ELN number (ELN ≥15, recommended group). Results: 39.4%. The Kaplan-Meier survival curve analysis of CSS demonstrated no statistical significance between the two groups (P=0.31). Moreover, the OS was similar between the two groups in the elderly GC patients who underwent total gastrectomy (P=0.16). However, the OS were significant shorter in the limited group in elderly GC patients who underwent proximal and distal gastrectomy (both P<0.001). Conclusions: Limited ELN number might be sufficient for elderly GC patients with total gastrectomy. Prospective studies with a larger sample size are required to validated these results.
Source: Translational Cancer Research
DOI: 10.21037/tcr-24-1477
Authors: Xiaojie Zhang, Tao Fu, Guochao Zhang, Haibin Liu, Lin Zhang, Zongze Li, Shengnan Zhou, Lei Zhou
Institution: China-Japan Friendship Hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4408685355