Work

Synergistic anti-inflammatory and anti-tb effects of Au-Pt-Cu nanofluids: experimental and computational insights

Year: 2025

Type: article

Abstract: Aims To explore the potent anti-inflammatory and anti-tuberculosis potential of novel trimetallic Au-Pt-Cu nanofluids.Materials & methods We employed BSA assay for anti-inflammatory assessment and tested anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv. Advanced molecular docking, dynamics, and DFT analyses were conducted to reveal interaction mechanisms and electronic properties.Results The nanofluids demonstrated impressive IC50 values (15.88 ± 0.09 μM and 0.54 ± 0.02 μg/ml), with strong binding affinities and stable interactions confirmed via molecular simulations. Favorable ADMET profiling highlights their promise as innovative therapeutic agents.

Source: Future Medicinal Chemistry

DOI: 10.1080/17568919.2025.2478818

Authors: Amit Dubey, Manish Kumar, Amer M. Alanazi, Aisha Tufail, Abhay D. Bagul

Institutions: Saveetha University, University of Allahabad, King Saud University, Government Institute of Forensic Science

Language: English

Topic: Nanoparticles: synthesis and applications

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: King Saud University