Proteasome condensates repeatedly “contact and release” at the nuclear periphery during dissolution
Year: 2025
Type: article
Abstract: , cytoplasmic proteasome condensates assemble from the nuclear proteasomes under glucose starvation conditions. Proteasome condensates rapidly dissipate, and proteasomes reimport to the nucleus within minutes upon glucose recovery. We characterize the kinetics and dynamics of proteasome condensates after glucose recovery. Proteasome condensates transiently associate nuclear membranes with a repetitive "contact and release" movement during dissolution. Our study provides new insight into the events leading to biomolecular condensate dissolution.
Source: PubMed
Authors: Conner Butcher, Kyle VanderVen, Jianhui Li
Institution: Florida Institute of Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4408688474