Age- and sex-specific reference values of estimated glomerular filtration rate for European adults
Year: 2025
Type: article
Abstract: Kidney function, often assessed by estimated glomerular filtration rate (eGFR), declines naturally with age. However, there is a lack of eGFR reference values to describe normal and abnormal values for a specific age. The European Chronic Kidney Disease Burden Consortium is comprised of nine participating general population-based studies from seven European countries which provides European age- and sex-specific eGFR reference values in healthy adults using the European Kidney Function Consortium (EKFC) equation. Of 2,572,020 individuals, 1,535,253 (60%) were considered healthy, of which 45% were men. Ages ranged from 18 to 105 years old in men and 18 to 107 years old in women with a median age of 43 years in both sexes. At age 20 in men, the 5 th , 50 th and 95 th eGFR percentiles were 78 ml/min per 1.73 m 2 , 99 ml/min per 1.73 m 2 , and 119 ml/min per 1.73 m 2 . In 20-year-old women this was 81 ml/min per 1.73 m 2 , 101 ml/min per 1.73 m 2 , and 121 ml/min per 1.73 m 2 . Consequently, in men aged 80 years old, the 5 th , 50 th and 95 th eGFR percentiles were 49 ml/min per 1.73 m 2 , 66 ml/min per 1.73 m 2 , and 84 ml/min per 1.73 m 2 . In 80 year old women this was 46 ml/min per 1.73 m 2 , 63 ml/min per 1.73 m 2 , and 81 ml/min per 1.73 m 2 . Overall, our study shows that eGFR is not preserved with ageing in healthy individuals and these eGFR reference values can help determine abnormal and normal kidney function across the age range.
Source: Kidney International
Authors: Megan E. Astley, Nicholas C. Chesnaye, Stein Hallan, Giovanni Gambaro, Alberto Ortiz, Juan-Jesus Carrero, Natalie Ebert, Bjørn Odvar Eriksen, Anne-Laure Faucon, Pietro Manuel Ferraro, Olafur S. Indridason, Till Ittermann, Arnar J. Jonsson, Knut Asbjørn Rise Langlo, Toralf Melsom, Elke Schaeffner, Sylvia Stracke, Vianda S. Stel, Kitty J. Jager
Institutions: Amsterdam UMC Location University of Amsterdam, Amsterdam Public Health, Norwegian University of Science and Technology, St Olav's University Hospital, University of Verona, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Danderyds sjukhus, Karolinska Institutet, Charité - Universitätsmedizin Berlin, University Hospital of North Norway, UiT The Arctic University of Norway, Inserm, Université Paris-Saclay, Centre de recherche en Epidémiologie et Santé des Populations, National University Hospital of Iceland, Universitätsmedizin Greifswald, Universität Greifswald, University of Iceland
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,500
Funders: Northern Clay Center, Amgen, Eli Lilly and Company, AstraZeneca, Bayer, Sanofi, Alexion Pharmaceuticals, Amicus Therapeutics, Fresenius Medical Care North America, European Commission, European Cooperation in Science and Technology, Hjärt-Lungfonden, Vetenskapsrådet, Ministry of Economic Affairs, Astellas Pharma, Swedish Orphan Biovitrum, KfH-Stiftung Präventivmedizin, Idorsia Pharmaceuticals, Instituto de Salud Carlos III, European Regional Development Fund
Awards: G1791132035, G2256342894, G2650182398, G2854544501, G4022723184, G4269780470, G451205262, G5123827200, G5165426654, G5699757257, G6889659775, G7583203578, Developing a framework/model to environmentally sustainable and climate neutral health and care systems using the Kidney care pathway, G8614953158, Spain CKD cause (SPACKDc)
OpenAlex ID: W4408732365