Work

105P Prognostic significance of tumor-infiltrating lymphocytes in rare sarcomas: A multicenter retrospective analysis

Year: 2025

Type: article

Abstract: Results: Weak to moderate membranous, cytoplasmic and nuclei immunolocalisation of the AF-6 were observed in endothelial cells of all the familial and the plexiform forms of neurofibromatosis type 1.Similarly, the AF-6 moderately localizes to the membrane of the endothelial cells of most of the sporadic neurofibroma studied.Conclusions: From this study, we suggest that the instability of chromosome 17 and neurofibromin that is located on it, may affect chromosome 6 together with afadin-6 in benign lesions such as familiar, plexiform and sporadic neurofibromas with varying severity.These may contribute to the loss of cell-cell adhesion and subsequent unregulated cell proliferation in neurofibromatosis type -1 and the potential of transformation to malignant peripheral nerve tumour (MPNST).

Source: ESMO Open

DOI: 10.1016/j.esmoop.2025.104418

Authors: Ahmed Elalfy, F. Azazzi

Institutions: Mansoura University, Ain Shams University

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910