Work

Optimal Dose of Intranasal Insulin Administration for Reducing Postoperative Delirium Incidence in Older Patients Undergoing Hip Fracture Surgery

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: OBJECTIVES: To investigate the effects of administration of different intranasal insulin doses on postoperative delirium (POD) incidence in older patients with hip fractures. DESIGN: Prospective, randomized, double-blinded, placebo-controlled trial (23K214-001, NCT06443957). SETTING: The First Hospital of Jilin University from July 2023 to February 2024. PATIENTS: Patients aged ≥65 years with hip fractures scheduled for elective unilateral hip arthroplasty or closed reduction and intramedullary nailing under spinal anesthesia. INTERVENTIONS: Patients were randomly divided into a Control group (n = 43, 1 ml normal saline administered intranasally) or I-20 group (n = 45, 1ml 20U/ml insulin administered intranasally) or I-40 group (n = 42, 1ml 40U/ml insulin administered intranasally). MEASUREMENTS: POD incidence within postoperative days 1-3 was recorded. Fingertip blood glucose levels were recorded 40 min after insulin or saline administration the day before surgery, operating room entry and immediately after the procedure. Cerebrospinal fluid (CSF) glucose and lactate levels were also measured. RESULTS: Compared with the Control group, the I-20 and I-40 groups showed significantly lower POD incidence (39.5% versus 11.4% versus 14.3%, p = 0.002). Furthermore, no significant difference in POD incidence was observed between the I-20 and I-40 groups. CSF glucose levels were significantly higher in the I-40 group than in the Control group (p <0.0167). CSF lactate and fingertip blood glucose levels were not significantly different among the groups. CONCLUSION: Intranasal insulin administration at doses of 20U and 40U effectively reduces the incidence of POD in older patients with hip fractures without lowering peripheral blood glucose levels.

Source: American Journal of Geriatric Psychiatry

DOI: 10.1016/j.jagp.2025.03.009

Authors: Yue Li, Yue Zhang, Yuqi Ren, Huanqiu Liu

Institutions: First Hospital of Jilin University, Jilin University

Language: English

Topic: Intensive Care Unit Cognitive Disorders

Subfield: Critical Care and Intensive Care Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,400