Work

135P Management of sarcomas in adolescents and young adults (AYAs) in Spain

Year: 2025

Type: article

Abstract: type, the negative association of PPI use on treatment response was not significant.Additionally, there was statistically significant negative association between the use PPIs and adverse events (p < 0.05). Conclusions:We demonstrated that the concomitant use of PPIs at baseline with pazopanib in patients affected by STS is associated with a detrimental effect on OS and response to treatment.However, results show a potential protective effect of PPIs against adverse events.The potential drug-drug interaction between PPIs and pazopanib warrants careful consideration in treatment planning and patient management to optimize therapeutic efficacy, safety and outcomes.

Source: ESMO Open

DOI: 10.1016/j.esmoop.2025.104448

Authors: A. Soldado-Serrano, D. Maroto-Morales, A. Carrillo Llamas, A. Muñoz-Lerma, L. Castillo Portellano, C.M. Valverde Morales

Institutions: Hospital Universitario Virgen de las Nieves, Vall d'Hebron Hospital Universitari

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,910