Effect of β-Tri-calcium Phosphate in Both Its Putty and Granular Forms in Treating Bone Defects in Sheep
Year: 2025
Type: article
Abstract: Background: Finding a new and effective treatment for fractures and bone deformities in humans and animals is a priority in the medical and dentistry professions, β-tri-calcium phosphate in its two forms is one of these substances that our study focused on. Aim: to evaluate and compare the effect of β-tri-calcium phosphate granules and Putty on healing of bony defect after induced injury on tibia bone of sheep. Methods: Four healthy local breed male sheep all the sheep from the same farm. Four intervals were performed (2 weeks, 4 weeks, 6 weeks, 8 weeks). One tibia in each sheep was operated at two weeks interval period between each surgery (one surgery on each sheep making a total observation period of eight weeks). After two weeks of the last operation, the animals were euthanized based on a scheduled timeline. Results: The study reveals significant changes in osteoblasts, osteocytes, new capillaries, and histomorphometric measurements of bone marrow space over time,The study presents histological sections of sheep treated with granules and putty, revealing changes in bone marrow space histomorphometry and the presence of bone cells and capillaries. Conclusion: Although both kinds of β-TCP puty and granules considerably improved bone fracture healing, the β-TCP putty demonstrated a better and faster healing ability than the granules, with a marked improvement in the bone marrow area.
Authors: Abdulah M Salih, Saif S Al-Jewari
Institution: University of Mosul
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4408745244