Organocatalyzed α‐Deuteration of Ketones and Bioactive Carbonyl Compounds Using D 2 O as Deuterium Source
Year: 2025
Type: article
Abstract: In this report, we disclose an organocatalyzed deuteration process of α‐C‐H bonds in ketones using D 2 O as economical deuterium source under mild reaction conditions. This protocol enables good to excellent deuterium incorporation (90%–97%) in diverse ketones in a single run. The value of this methodology is further demonstrated by deuteration of commercially available bioactive ketones such as 2‐acetylphenothiazine, nabumetone, pentoxifylline, and estrone‐3‐methyl ether. Furthermore, the practicality of the developed protocol is justified by scale‐up studies.
Source: ChemistrySelect
Authors: Pooja Goyal, Akhil K. Dubey, Raghunath Chowdhury
Institutions: Bhabha Atomic Research Centre, Homi Bhabha National Institute
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,880
OpenAlex ID: W4408747641