Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
Year: 2025
Type: article
Abstract: • Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive decline. • Vitamins have antioxidant property that neutralizes free radicals that protect the neuronal cell to form oxidative damage, preventing lipid peroxidation and enhance brain function. • Vitamins prevent AD by reducing oxidative stress, lowering homocysteine levels and protecting cognitive function through multiple metabolic pathways and mechanisms. Alzheimer's disease (AD) is the most prevalent progressive neurodegenerative disease often characterized by memory loss, cognitive decline, and behavioral changes. The actual pathophysiology of AD remains unclear, but several factors including genetic, environmental, and lifestyle contribute significantly to the pathogenesis of AD. Even after over two decades of combined efforts to create novel interventions that can retard the progress of the disease, researchers still only have a small number of alternate medicines with poor efficacy. There is a recent growth of interest in the role of nutrients in brain health as we learn more about what nutrients are and how they impact hormonal and neurological processes that can result in a variety of neurological and psychiatric conditions. Additionally, deficiency of vitamins also gained attention for their pivotal roles in cognitive health. Vitamins, a crucial dietary supplement, regulate various physiological functions and maintain neuronal health, energy metabolism, and antioxidant defence. Vitamin B, such as B1, B6, and B12, are chief constituents for the metabolism of homocysteine and the release of neurotransmitters, a decrease in vitamin E and D may result in increased oxidative damage, which further contributes to neuronal loss. Vitamin deficiencies may make AD degenerative processes more severe as increased amyloid-beta (Aβ) plaque development and tau protein phosphorylation, are two characteristics of AD. This review explores a comprehensive summary of the most widely used vitamins and discusses the findings of recent research on the relationship between these vital micronutrients and AD.
Source: Aging and Health Research
Authors: Vipul Sharma, Khadga Raj Aran
Institution: Indo Soviet Friendship College of Pharmacy
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,380
OpenAlex ID: W4408751067