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Itraconazole-associated purpuric drug eruption: a rare adverse effect of a commonly prescribed drug

Year: 2025

Type: article

Abstract: Purpuric drug eruption (PDE) is a rare drug reaction characterized by purpuric macules, papules and confluent plaques predominantly on the lower extremities. The drugs reported to induce PDE are epidermal growth factor receptor inhibitors, ketoconazole, acetylsalicylic acid, penicillin, sulfonamides, indomethacin, lenalidomide, linezolid and vancomycin. Drug-induced thrombocytopenia, platelet dysfunction and direct toxic effects of the drug on the capillary wall leading to increased capillary fragility are the proposed aetiologies. There is only a single report of itraconazole-induced PDE in the literature to date. We herein present a case of 57-year-old woman with PDE due to itraconazole.

Source: Skin Health and Disease

DOI: 10.1093/skinhd/vzaf006

Authors: Mahesh Mathur, Sandhya Regmi, Sumit Paudel, Supriya Paudel, Nabita Bhattarai, Sambidha Karki

Institution: College of Medical Sciences

Language: English

Topic: Drug-Induced Adverse Reactions

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,597