Work

Phlorizin Prolongs the Lifespan of Caenorhabditis elegans by Insulin and SIR-2.1 Regulation

Year: 2025

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Phlorizin has significant antioxidant properties and was studied using Caenorhabditis elegans to explore potential antiaging mechanisms. Results showed that phlorizin mitigated the harmful effects of high temperatures and hydrogen peroxide, reduced oxidative stress, increased antioxidant enzyme activity, and reduced malondialdehyde levels. Network pharmacological analysis reveals that the AKT1, INSR, and SOD2 signaling pathways play a key role in the antiaging effects of phlorizin. Its action is mediated by insulin and SIR-2.1, influencing DAF-16, SKN-1, and downstream genes in the antiaging effects. This implicates phlorizin as a promising functional food additive targeting the DAF-16 and SOD-3 axes for antiaging.

Source: ACS Omega

DOI: 10.1021/acsomega.4c08725

Authors: Xiaohan Zhang, Hao Wang

Institutions: Tianjin University of Science and Technology, State Key Laboratory of Food Nutrition and Safety, Dalian Polytechnic University

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,935