Prognosis analysis of sacrococcygeal teratoma—compared with patient size
Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Advancements in prenatal care have underscored the importance of understanding postnatal outcomes and prognosis in sacrococcygeal teratoma (SCT). However, giant SCTs continue to pose surgical challenges and are associated with increased morbidity and mortality. A clear, objective threshold for defining a "large" tumor relative to the patient's size remains undefined. This study aimed to establish objective tumor size indicators for predicting surgical outcomes and prognosis. Methods: Data from 97 patients diagnosed with and surgically treated for SCT at Asan Medical Center from 2000 to 2021 was retrospectively reviewed. The tumor volume/birthweight ratio (VWR) and tumor length/height at birth ratio (LHR) were measured. Surgical outcomes and prognosis were evaluated based on these measures, including surgical complications, concomitant surgeries, long-term complications, and recurrence. Results: After surgery, 38 patients experienced short-term complications, 18 required additional operations, 16 developed long-term complications, and 14 experienced tumor recurrence. Both VWR and LHR correlated with short and long-term complications, additional surgeries, and recurrence. Discussion: The small patient population limited the determination of precise cut-off values; however, a significant difference was observed between groups stratified by the most predictive cut-off values. Both objective tumor size indicators were significantly associated with prognosis and surgical outcomes. Notably, both indicators exhibited comparable predictive capabilities without discrepancies.
Source: Frontiers in Pediatrics
Institutions: Asan Medical Center, University of Ulsan
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4408768668