Work

Recurrent anemia due to mucosal prolapse syndrome

Year: 2025

Type: article

Abstract: Mucosal prolapse syndrome is a rare group of benign disorders mainly in the rectum. It often causes rectal bleeding, abdominal pain, and anaemia. We report a case of severe anaemia due to mucosal prolapse syndrome requiring blood transfusion. A 36-year-old man was referred for further evaluation of recurrent iron deficiency anaemia. Initial examinations, including esophagogastroduodenoscopy, colonoscopy, and capsule endoscopy, revealed no significant abnormalities other than rectal mucosal prolapse syndrome without notable bleeding. Nine months later, despite oral iron therapy, the patient developed bloody stools and severe anaemia (haemoglobin 6.2 g/dl), requiring a transfusion. Colonoscopy showed an enlarged mucosal prolapse, which was strongly suspected as the cause of the anaemia, leading to a transanal lumpectomy. Postoperatively, the patient has remained symptom-free, with no recurrence of anaemia or bloody stools. While mucosal prolapse syndrome is an rare condition, clinicians should remain vigilant about its potential to cause severe anaemia requiring blood transfusion. LEARNING POINTS: Mucosal prolapse syndrome (MPS) is a benign group of conditions associated with mucosal prolapse and can appear in a variety of forms, mainly in the rectum.Although MPS is rare, clinicians should remain vigilant as it can lead to severe anaemia requiring blood transfusions.

Source: European Journal of Case Reports in Internal Medicine

DOI: 10.12890/2025_005314

Authors: Tetsu Sakamoto, Takanobu Hirosawa, Taro Shimizu

Institution: Dokkyo Medical University

Language: English

Topic: Gastrointestinal Bleeding Diagnosis and Treatment

Subfield: Gastroenterology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $323