HIV pre-exposure prophylaxis uptake and associated factors among HIV serodiscordant heterosexual couples in Nairobi City County, Kenya
Year: 2025
Type: article
Study design: Observational Study
Abstract: HIV antiretroviral drugs used as pre-exposure prophylaxis (PrEP) are effective for HIV prevention. This study evaluated determinants of PrEP uptake among HIV-negative spouses in HIV-serodiscordant heterosexual relationships in Nairobi City County, Kenya. Of the 424 participants, 114 reported current PrEP use, resulting in a PrEP uptake of 27% (23–31%). The top reason for current PrEP use was to achieve pregnancy (n = 69; 61%). Of the 424 participants, 209 (49%) had never used PrEP, and the leading reasons for never using PrEP were lack of PrEP information (38%) and self-perceived low risk for HIV (36%). Factors associated with decreased likelihood of PrEP use included: low level of education (p = 0.026), self-perception of being at low-to-no risk for HIV (p = 0.021), lack of desire for more children (p = 0.005) and lack of knowledge that PrEP is offered free (p = 0.004). Female sex (aOR = 2.3; 95% CI: 1.4–4.0) and lack of condom use (aOR = 2.5; 95% CI: 1.4–4.5) were associated with increased odds of taking PrEP. Uptake of PrEP among HIV-serodiscordant couples in Nairobi City County was low, and PrEP use was driven by desire to fulfill pregnancy intentions. Aggressive educational campaigns to address self-HIV-risk perceptions and increase PrEP knowledge are necessary for increased PrEP demand.
Source: AIDS Care
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4408777757