Overexpression of adipose tissue ERα enhances PVAT anticontractility via NOX4-derived H 2 O 2 and is protective against high-fat diet-induced dysfunction
Year: 2025
Type: article
Abstract: We have revealed for the first time that overexpression of adipose tissue estrogen receptor α (ERα OE ) amplifies the anticontractile effect of mesenteric PVAT via the biosynthesis of NADPH oxidase 4 (NOX4)-derived hydrogen peroxide (H 2 O 2 ), and this overexpression is protective against HFD-induced PVAT dysfunction. Collectively, these data demonstrate an important mechanism by which ERα signaling is vasculoprotective in the context of PVAT.
Institution: University of South Carolina
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: American Heart Association, National Institutes of Health, Office of the Vice President for Research, University of South Carolina, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Complementary and Integrative Health
Awards: G2161091158, G2674052081, Center for Targeted Therapeutics, G3871543562, G4259526058, G5462417587, G58725747, G6495206102, G873170453, Decoding the impact of O-GlcNAc, Sex, and Age on Cardiovascular Disease, G9000021902, G9000126961, LRRC8 anion channels, superoxide and RhoA in diabetic erectile dysfunction
OpenAlex ID: W4408779167