Work

AID/APOBEC: an expanding repertoire of targets and functions

Year: 2025

Type: article

Abstract: Deaminases belonging to the AID/APOBEC family are known as ssDNA and mRNA mutators involved in innate/adaptive immunity, mRNA editing, genome stabilization by restricting retrotransposons, and carcinogenesis. Recent studies suggest that the repertoire of AID/APOBEC targets is more diverse than previously thought and imply a broader biological impact of these proteins.

Source: Trends in Biochemical Sciences

DOI: 10.1016/j.tibs.2025.02.006

Authors: Lucyna Budzko, Aleksandra Mierzwa, Marek Figlerowicz

Institutions: InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Polish Academy of Sciences

Language: English

Topic: RNA regulation and disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030