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Efficacy of Age-Adjusted Dyspnea, Eosinopenia, Consolidation, Acidemia and Atrial Fibrillation Score in Predicting Long-Term Survival in COPD-Related Persistent Hypercapnic Respiratory Failure

Year: 2025
Type: article
Study design: Observational Study
Abstract: Background and Objectives: Data on the prognosis of hypercapnic respiratory failure (HRF) are limited, despite existing studies focusing on its causes and association with mortality. This study aimed to evaluate prognostic factors influencing long-term survival in patients with HRF due to chronic obstructive pulmonary disease (COPD) and to assess the effectiveness of the Age-adjusted Dyspnea, Eosinopenia, Consolidation, Acidemia and Atrial Fibrillation (A-DECAF) score. Materials and Methods: This retrospective study included patients admitted to the intensive care unit from the emergency department with HRF between April 2022-November 2023. Demographic data, comorbidities, laboratory results, and treatment protocols were recorded. A-DECAF scores were calculated, and survival was analyzed using Kaplan-Meier and ROC analysis. Results: Among 357 patients, 24.4% died within one year of discharge. Deceased patients had significantly higher mean ages (p<0.001) and higher APACHE-II, DECAF and A-DECAF scores (p<0.001). ROC analysis showed that A-DECAF had the highest sensitivity (93.1%) and accuracy (AUC=0.813) for predicting survival. Kaplan-Meier analysis indicated that higher A-DECAF scores were associated with reduced survival rates. Conclusion: The A-DECAF score is an effective tool for predicting long-term survival in COPD patients with HRF, particularly aiding clinical decisions in elderly populations. Further research is needed to validate its use in diverse patient groups.
Source: Life
DOI: 10.3390/life15040533
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $3,137
OpenAlex ID: W4408781950
FWCI: 1.765
Cites: 18
Cited by: 3
Related to: 10