Work

Fidaxomicin’s Role in Overcoming Vancomycin Failure in Clostridium difficile Infections: A Case Series and Literature Review

Year: 2025

Type: article

Abstract: infection (CDI), characterized by diarrheal illness with serious complications, is a common pathology in clinical practice. We present a series of five patients with CDI who underwent treatment with fidaxomicin following the failure of oral vancomycin. To our knowledge, no evidence in the literature suggests that fidaxomicin is more effective than vancomycin in treating acute infection. This paper emphasizes the importance of utilizing a large study to determine the relative effectiveness of vancomycin versus fidaxomicin in treating CDI. We also provide a literature review on CDI and management evolution.

Source: Cureus

DOI: 10.7759/cureus.81110

Authors: Mohammad Kloub, Shefali Pati, Ahmad W Haddad, Yazeed Abu Ruman, Qusai Al-Maharmeh, Mohammad Nabil Rayad, Bereket Tewoldemedhin, Jihad Slim

Institutions: Saint Michael's Medical Center, St. George's University

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4408787001

FWCI:

Cites: 32

Cited by:

Related to: 10