Work

Origin of poorly galactosylated IgA1 other than mucosa: a viewpoint from a report on patient with IgA vasculitis

Year: 2025

Type: article

Abstract: Patients presenting monoclonal gammopathy of renal significance (MGRS) and IgA vasculitis collectively have rarely been reported. This study reports one patient with monoclonal IgA and λ, and with IgA positive-mesangial proliferative glomerulonephritis. The patient manifested slight chronic nephritic syndrome, and his serums tested positive for M protein (monoclonal IgA and λ). As a result of bone wear, the plasma cell ratio of these patients was confirmed to be mildly increased in peripheral blood smears. Just like typical IgA nephropathy or IgA vasculitis patients, serum poorly galactosylated IgA1 antibodies were found in the patient compared to the controls. The patient was diagnosed with mild mesangial proliferative IgA vasculitis based on renal biopsy. Besides, immunofluorescence/immunohistochemistry confirmed immune deposits predominantly containing galactose-deficient IgA1 (GD-IgA1) and λ in the glomerular mesangium and the walls of the skin's blood vessels. The pathological findings support the hypothesis that monoclonal IgA, which originate from bone marrow plasma cells, rather than mucosally primed B cells, also may be galactose deficient. This may be a new pathological source of IgA-proliferative glomerulonephritis.

Source: Renal Failure

DOI: 10.1080/0886022x.2025.2479572