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Malignant Hidradenoma of the Scalp: A Rare Case with Diagnostic Challenges and Immunohistochemical Insights

Year: 2025

Type: article

Abstract: Introduction: Hidradenocarcinoma is an extremely rare and aggressive malignant tumor originating from eccrine sweat glands. It typically presents with nonspecific clinical features, which makes early diagnosis challenging. The tumor is known for its potential for recurrence and metastasis, often complicating management. Case Presentation: A 57-year-old male presented with a painless, gradually enlarging swelling on the scalp, which had been present for 2.5 years. Initially suspected to be an infected sebaceous cyst, the lesion was excised. Histopathological analysis revealed malignant hidradenoma, characterized by clear cytoplasm, nuclear pleomorphism, and increased mitotic activity. Immunohistochemical staining showed 22% Ki-67 and 14% p53 expression, confirming malignancy. No metastasis was found. Conclusion: Malignant hidradenoma is a rare and aggressive cutaneous tumor that can be challenging to diagnose due to its nonspecific presentation. Early recognition and wide surgical excision are essential for better prognosis and to prevent recurrence or metastasis.

Source: Skin Appendage Disorders

DOI: 10.1159/000545383

Authors: Anuradha Calicut Kini Rao, Rakshatha Nayak, P.S.M. Ameer Ali, Shikha Jayasheelan, Kudurugundi Basavaraju Vatsala

Institutions: Manipal Academy of Higher Education, Kasturba Medical College, Manipal, Kasturba Medical College, Mangalore, Yenepoya University

Language: English

Topic: Cancer and Skin Lesions

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4408796084

FWCI:

Cites: 8

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Related to: 10