Work

Antiproliferative effects, mechanism of action and tumor reduction studies in a lung cancer xenograft mouse model of an organometallic gold( i ) alkynyl complex

Year: 2025

Type: article

Abstract: An organometallic anticancer drug candidate with a mechanism related to TrxR inhibition and mitochondrial respiration inhibition shows efficient in vivo antitumor efficacy.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00964a

Authors: Uttara Basu, Anna Wilsmann, Sebastian Türck, Henrik Hoffmeister, Matthias Schiedel, Gilles Gasser, Ingo Ott

Institutions: Birla Institute of Technology and Science, Pilani - Goa Campus, Birla Institute of Technology and Science, Pilani, Technische Universität Braunschweig, Centre National de la Recherche Scientifique, Chimie ParisTech - PSL, Université Paris Sciences et Lettres, Chimie Biologique pour le Vivant, Institute of Chemistry for Life and Health Sciences

Language: English

Topic: Metal complexes synthesis and properties

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Deutsche Forschungsgemeinschaft, Birla Institute of Technology and Science, Pilani, European Research Council, Science and Engineering Research Board

Awards: G1391751571, G5333622838, G5611310860, G6698491493, Medizinische und Biologische Chemie von AlkinylgoldKomplexen

OpenAlex ID: W4408798921

FWCI: 1.49

Cites: 59

Cited by: 4

Related to: 10