Work

Intraamniotic vitamin D preserves lung development and prevents pulmonary hypertension in experimental bronchopulmonary dysplasia due to intraamniotic sFlt-1

Year: 2025

Type: article

Abstract: This study highlights that experimental BPD induced by intraamniotic sFlt-1 is associated with impaired growth in postnatal pulmonary endothelial cells. We demonstrate that 1,25(OH) 2 D may be a therapeutic option to improve lung development through enhancement of VEGF signaling and preservation of early pulmonary endothelial growth in the newborn rat lung.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00409.2024

Authors: Michael W. Cookson, Tania Gonzalez, Elisa M. Bye, Greg Seedorf, Sarah Ellor, Bradford J. Smith, James C. Fleet, Erica W. Mandell

Institutions: Children's Hospital Colorado, University of Colorado Anschutz, University of Colorado Denver

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Academy of Pediatrics, National Institutes of Health, National Heart, Lung, and Blood Institute, National Center for Advancing Translational Sciences

Awards: G1544622754, G7352434647, Colorado Clinical and Transational Sciences Institute, Multidisciplinary Research Training in Pediatric Pulmonary Vascular Disease

OpenAlex ID: W4408799554

FWCI: 1.772

Cites: 66

Cited by: 3

Related to: 10