Toxicity Effect of Arsenic Trioxide on Hematological (RBC, WBC & Hemoglobin) and Morphological (Outside Body Reaction) Parameters in Mus musculus: A Comparative Study with Oral Administration of Control and Dose Groups
Year: 2025
Type: article
Abstract: : Arsenic trioxide (As₂O₃) is a potent environmental toxin that affects hematological parameters and induces morphological abnormalities in mammals. This study investigates the toxicity effects of arsenic trioxide on red blood cells (RBC), white blood cells (WBC), hemoglobin levels, and external morphological changes such as body weight, fur texture, and behavioral responses in Musmusculus. A comparative analysis was conducted between a control group and multiple dose groups receiving arsenic trioxide via oral administration. Statistical analysis using the t-test was performed to determine the significance of hematological and morphological variations. The results showed a significant decline in RBC count and hemoglobin concentration, an initial surge followed by suppression in WBC count, and notable morphological changes, including weight loss and fur deterioration. The findings highlight the hazardous impact of arsenic exposure and emphasize the need for regulatory measures to mitigate its toxic effects.
Authors: Sumit Kumar, Ashok Kumar Thakur
Institution: Tilka Manjhi Bhagalpur University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4408812181