Work

An allosteric inhibitor targeting the STAT3 coiled-coil domain selectively suppresses proliferation of breast cancer

Year: 2025

Type: article

Abstract: ) markedly suppressed tumor growth and inhibited STAT3 activity in a 4T1 cell-derived murine breast cancer model. Overall, our results provided pharmacological evidence supporting future clinical investigation of K116 as a promising STAT3 CCD allosteric inhibitor for breast cancer treatment.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00926f

Authors: Min Huang, Wei Wang, Liyue Cao, Jiaxin Liu, Can Du, Jian Zhang

Institutions: Northwestern Polytechnical University, Qinghai Provincial Peoples Hospital, Shanghai Jiao Tong University

Language: English

Topic: Cytokine Signaling Pathways and Interactions

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Natural Science Foundation of Shaanxi Province