Work

Knockdown of TXNIP attenuates methylmercury toxicity in mouse neuronal C17.2 cells

Year: 2025

Type: article

Abstract: Methylmercury is an environmental pollutant that causes severe central nervous system damage. However, the mechanism involved in its toxicity remains unclear. In this study, expression of thioredoxin-interacting protein (TXNIP), which is involved in the regulation of intracellular redox status, was rapidly induced in mouse neuronal C17.2 cells in response to methylmercury exposure. In addition, C17.2 cells transfected with small interfering RNA against TXNIP mRNA showed greater resistance to methylmercury than control cells. These findings suggest that TXNIP is a novel factor involved in enhancing methylmercury toxicity and that methylmercury may cause cell death by inducing TXNIP expression.

Source: Fundamental Toxicological Sciences

DOI: 10.2131/fts.12.29

Authors: Ryoko Fukushima, Naoya Yamashita, Soujun Yadoya, Ryota Yamagata, Gi-Wook Hwang

Institution: Tohoku Medical and Pharmaceutical University

Language: English

Topic: Mercury impact and mitigation studies

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science