The impact of clot permeability on platelet fluxes toward its surface
Year: 2025
Type: article
Abstract: Platelet aggregation is regulated by a series of chemical reactions that control platelet adhesion on a thrombogenic surface. These reactions are influenced by the complex interaction between reaction kinetics and hemodynamics. This study systematically investigates the transport of platelets, considering the interaction between flow-mediated mass transfer mechanisms and reaction kinetics as a function of clot permeability. A two-dimensional finite element model is developed to replicate static blood flow, platelet transport, and adhesion on a semi-elliptical and semi-circular structure representing permeable clots. The platelet-clot interface interactions are extensively investigated using a hindered transport model, focusing on clot permeabilities, reaction rates, and flow conditions. In the case of clots with highly reactive surfaces, an increase in clot permeability can lead up to four-fold increase in total platelet flux compared to non-permeable clots due to differences in transport environments.
Source: PLoS ONE
Institution: University of Amsterdam
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,382
OpenAlex ID: W4408815535