Work

Prolonged unilateral renal ischemia-reperfusion as a model for acute to chronic kidney injury in female mice

Year: 2025

Type: article

Abstract: Our findings identify a reliable timepoint at which female mice subjected to unilateral ischemia-reperfusion consistently develop CKD changes relative to much shorter duration in male mice. We provide a novel model to study the AKI-CKD transition in female mice.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00280.2024

Authors: Kaitlynn Stowers, Valeria Rudman-Melnick, Qing Ma, Prasad Devarajan

Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases