Work

Copy-number alterations in cell-free DNA can be transient or harbingers of clonal hematopoiesis

Year: 2025

Type: article

Study design: Observational Study

Abstract: Genome-wide plasma cfDNA pan-cancer screening of 1002 healthy elderly identified 15 individuals with CNAs of unknown origin. Nine participants were reassessed over 3-5 years through health questionnaires, WB-MRI, and cfDNA and blood analyses. CNAs resolved in two cases but persisted in seven mainly associated with low-grade clonal mosaicism. These findings suggest cfDNA CNAs may be transient or serve as early markers of clonal mosaicism, preceding clinical detection by years.

Source: npj Precision Oncology

DOI: 10.1038/s41698-025-00877-x

Authors: Stefania Tuveri, Nathalie Brison, Tatjana Jatsenko, Barbara Dewaele, Cindy Melotte, Charlotte Maggen, Vincent Vandecaveye, Peter Vandenberghe, Frederic Amant, Liesbeth Lenaerts, Joris R. Vermeesch

Institutions: KU Leuven, Universitair Ziekenhuis Leuven, Universitair Ziekenhuis Brussel, The Netherlands Cancer Institute

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,090

Funders: Fonds Wetenschappelijk Onderzoek, KU Leuven, Kom op tegen Kanker, Vlaamse regering, Universitaire Ziekenhuizen Leuven, KU Leuven

Awards: G352573182, MICADO: Multiomic Integration of cell-free DNA profiles to Advance Disease Outcome, G4527036310, cfDNA genome-wide methylation profiling for pre-symptomatic cancer detection and typing, G6751753320

OpenAlex ID: W4408823813

FWCI: 0.325

Cites: 22

Cited by: 1

Related to: 10