Work

Kynurenine amplifies tetrahydrocannabinol-induced sensorimotor impairment and classic “tetrad” effects in mice

Year: 2025

Type: article

Abstract: BACKGROUND: -THC-induced sensorimotor and "tetrad" responses in mice. METHODS: -THC and its metabolites concentrations after the treatments were also evaluated. RESULTS: -THC and its psychoactive metabolite 11-OH-THC plasma levels were higher in mice pretreated with KYN than in control mice. CONCLUSIONS: The present data indicate for the first time that KYN amplifies the THC-induced sensorimotor impairment and classic "tetrad" response possibly through a pharmacokinetic interaction.

Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI: 10.1016/j.pnpbp.2025.111342